Glucosamine and MSM (Methyl Sulfonyl Methane) occur abundantly in joint tissue and are required for the repair and maintenance of these areas. The health benefits of glucosamine have recently been recognized and approved by Health Canada to help in the relief of joint pain associated with osteoarthritis, to protect against the deterioration of cartilage and to be an important factor in the building of healthy cartilage. MSM was isolated in the early 80's. Research has shown that MSM is a natural sulfur compound found in all living things and is made up of 34% sulfur. MSM levels in joint tissue decline with age, resulting in the deterioration of cartilage and osteoarthritis symptoms. MSM has shown benefits for a range of health problems including arthritis, muscle and joint pain. As a natural pain reliever, MSM plays an important role in the inhibition of pain impulses along nerve fibers, lessening of inflammation, blood supply increase, as well as muscle spasm reduction. MSM is usually used in combination with effective joint supplements glucosamine, acting as synergistic ingredients for arthritis related joint discomfort due to joint pain. MSM helps the glucosamine do its job more effectively. Principal Effects Monograph of Health Canada: Helps to relieve joint pain associated with osteoarthritis Helps to relieve pain associated with osteoarthritis of the knee Helps to protect against the deterioration of cartilage A factor in maintaining heathy cartilage and/or joint health Ingredients per tablet: Glucosamine sulfate 500 mg MSM (methylsulfonylmethane) 500 mg Non-medicinal ingredients: Microcrystalline cellulose, Magnesium stearate. NPN: 80008867