CAFFEINE IS USED FOR: - HELPS (TEMPORARILY) TO PROMOTE ALERTNESS AND WAKEFULNESS, AND TO ENHANCE COGNITIVE PERFORMANCE. - HELPS (TEMPORARILY) TO RELIEVE FATIGUE, TO PROMOTE ENDURANCE, AND TO ENHANCE MOTOR PERFORMANCE. - USED (TEMPORARILY) AS A MILD DIURETIC. CAUTION AND WARNING CONSULT A HEALTH CARE PRACTITIONER PRIOR TO USE IF YOU ARE TAKING LITHIUM. CONSULT A HEALTH CARE PRACTITIONER PRIOR TO USE IF YOU HAVE HIGH BLOOD PRESSURE, GLAUCOMA, AND/OR DETRUSOR INSTABILITY (OVERACTIVE BLADDER SYNDROME). CONSUMPTION WITH NATURAL HEALTH PRODUCTS (E.G. BITTER ORANGE EXTRACT, SYNEPHRINE, OCTOPAMINE, EPHEDRA) OR OTHER DRUGS (E.G. EPHEDRINE) WHICH INCREASE BLOOD PRESSURE IS NOT RECOMMENDED. CONSUMPTION WITH OTHER CAFFEINE-CONTAINING PRODUCTS (E.G. MEDICATIONS, COFFEE, TEA, COLAS, COCOA, GUARANA, MAT�) IS NOT RECOMMENDED. THIS PRODUCT IS NOT INTENDED AS A SUBSTITUTE FOR SLEEP. HYPERSENSITIVITY/ALLERGY IS KNOWN TO OCCUR, IN WHICH CASE, DISCONTINUE USE ARYA LA, MYERS DL, JACKSON ND. DIETARY CAFFEINE INTAKE AND THE RISK FOR DETRUSOR INSTABILITY: A CASE-CONTROL STUDY. OBSTETRICS AND GYNECOLOGY 2000;96(1):85-89. ASHIHARA H, SUZUKI T. DISTRIBUTION AND BIOSYNTHESIS OF CAFFEINE IN PLANTS. FRONTIERS IN BIOSCIENCE 2004;9:1864-1876. AVISAR R, AVISAR E, WEINBERGER D. EFFECT OF COFFEE CONSUMPTION ON INTRAOCULAR PRESSURE. THE ANNALS OF PHARMACOTHERAPY 2002;36(6):992-995. BERARDI RR, DESIMONE EM, NEWTON GD, OSZKO MA, POPOVICH NG, ROLLINS CJ, SHIMP LA, TIETZE KJ, EDITORS. HANDBOOK OF NONPRESCRIPTION DRUGS: AN INTERACTIVE APPROACH TO SELF-CARE, 13TH EDITION. WASHINGTON (DC): AMERICAN PHARMACEUTICAL ASSOCIATION; 2002. BOUCHARD NC, HOWLAND MA, GRELLER HA, HOFFMAN RS, NELSON LS. ISCHEMIC STROKE ASSOCIATED WITH USE OF AN EPHEDRA-FREE DIETARY SUPPLEMENT CONTAINING SYNEPHRINE. MAYO CLINIC PROCEEDING 2005;80(4):541-545. BUI LT, NGUYEN DT, AMBROSE PJ. BLOOD PRESSURE AND HEART RATE EFFECTS FOLLOWING A SINGLE DOSE OF BITTER ORANGE. THE ANNALS OF PHARMACOTHERAPY 2006;40(1):53-57. CHANDRASEKARAN S, ROCHTCHINA E, MITCHELL P. EFFECTS OF CAFFEINE ON INTRAOCULAR PRESSURE: THE BLUE MOUNTAINS EYE STUDY. JOURNAL OF GLAUCOMA 2005;14(6):504-507. CHRISTOPHER G, SUTHERLAND D, SMITH A. EFFECTS OF CAFFEINE IN NON-WITHDRAWN VOLUNTEERS. HUMAN PSYCHOPHARMACOLOGY 2005;20(1):47-53. CORNELIS MC, EL-SOHEMY A. COFFEE, CAFFEINE, AND CORONARY HEART DISEASE. CURRENT OPINION IN LIPIDOLOGY 2007;18(1):13-19. CREIGHTON SM, STANTON SL. CAFFEINE: DOES IT AFFECT YOUR BLADDER? BRITISH JOURNAL OF UROLOGY 1990;66(6):613-614. DOHERTY M, SMITH PM. EFFECTS OF CAFFEINE INGESTION ON RATING OF PERCEIVED EXERTION DURING AND AFTER EXERCISE: A META-ANALYSIS. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS 2005;15(2):69-78. This page is not intended to be a comprehensive review of the medicinal ingredient.